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Search for "process development" in Full Text gives 17 result(s) in Beilstein Journal of Organic Chemistry.
Inline purification in continuous flow synthesis – opportunities and challenges
Beilstein J. Org. Chem. 2022, 18, 1720–1740, doi:10.3762/bjoc.18.182
- chemistry tools developed in academia. Keywords: flow synthesis; inline purification; process development; reaction telescoping; scale-up; Introduction Continuous flow chemistry is a mature and widely applied platform technology that exploits intrinsic advantages over batch processing such as better heat
A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries
Beilstein J. Org. Chem. 2021, 17, 1181–1312, doi:10.3762/bjoc.17.90
- companies further down the supply chain for formulation, packaging and distribution. International fragrance companies are mainly responsible for the discovery, creation, process development and manufacturing of synthetic fragrance ingredients with all of these representing active areas of current research
Kinetics of enzyme-catalysed desymmetrisation of prochiral substrates: product enantiomeric excess is not always constant
Beilstein J. Org. Chem. 2021, 17, 873–884, doi:10.3762/bjoc.17.73
- when the reaction time is extended to reach preparative conversions. But the adverse effect (for some kinetic mechanisms) of higher concentrations of the prochiral starting material should also be noted. Very often process development will involve increasing these concentrations to try and obtain a
Clustering and curation of electropherograms: an efficient method for analyzing large cohorts of capillary electrophoresis glycomic profiles for bioprocessing operations
Beilstein J. Org. Chem. 2020, 16, 2087–2099, doi:10.3762/bjoc.16.176
- ; electropherogram; glycosylation; monoclonal antibodies; peak picking; process development; Introduction Glycosylation is important for the efficacy and function of a majority of the most dominant biologic drugs currently on the global market. In the case of antibody-based biotherapeutics, the absence of
- (CQA) of most biologics. This necessitates control of glycosylation processing during a drug process development stage to ultimately relay a consistent glycosylation of the biologic product during manufacturing [6]. This is difficult because glycosylation during fermentation occurs with a high degree
- to assess how glycans behave under these diverse conditions. During this process development of antibody-based drugs, the N-glycosylation of an antibody can deviate from their expected glycomic profiles as a result of fluctuations in culture conditions and operating parameters. Therefore, to assess
In silico rationalisation of selectivity and reactivity in Pd-catalysed C–H activation reactions
Beilstein J. Org. Chem. 2020, 16, 1465–1475, doi:10.3762/bjoc.16.122
- desired. Recent years have seen the emergence of new methods of research in chemistry and process development, which include high-throughput experiments [3], autonomous self-optimising reactors [4][5][6], as well as predictions of reaction outcomes and of reaction conditions based on machine learning (ML
- and the appropriate mechanism, but also provides information for further kinetic studies and process development, thus contributing to the development of robust new chemical transformations. An approximate energy map for the electrophilic aromatic substitution mechanism. Schematic representation of
Encaging palladium(0) in layered double hydroxide: A sustainable catalyst for solvent-free and ligand-free Heck reaction in a ball mill
Beilstein J. Org. Chem. 2017, 13, 1661–1668, doi:10.3762/bjoc.13.160
- Wei Shi Jingbo Yu Zhijiang Jiang Qiaoling Shao Weike Su National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014
An eco-compatible strategy for the diversity-oriented synthesis of macrocycles exploiting carbohydrate-derived building blocks
Beilstein J. Org. Chem. 2017, 13, 1106–1118, doi:10.3762/bjoc.13.110
- Sushil K. Maurya Rohit Rana Natural Product Chemistry and Process Development Division, CSIR- Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176 061, India Academy of Scientific and Innovative Research, CSIR- Institute of Himalayan Bioresource Technology, Palampur
Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic
Beilstein J. Org. Chem. 2017, 13, 960–987, doi:10.3762/bjoc.13.97
- . also facilitate continuous separation and significantly reduce the time for process development. Recent reviews on multistep synthesis clearly highlight the potential application of multistep syntheses in fine and pharmaceutical industries [5][31][32]. However, while continuous-flow synthesis helps to
- speeding up the optimization, process development and actual translation of chemistry to products. This implies that integration of various core and peripheral domains from the relevant sciences and engineering is absolutely essential and unavoidable to automate on-demand and end-to-end synthesis of
Development of a continuous process for α-thio-β-chloroacrylamide synthesis with enhanced control of a cascade transformation
Beilstein J. Org. Chem. 2016, 12, 2511–2522, doi:10.3762/bjoc.12.246
- , with the resulting product typically ca. 94% pure by HPLC. It was also envisaged that the facility to superheat the solvent in a pressurised continuous platform could enable sodium ethoxide to be replaced by a weaker base, obviating the need for sodium metal. At an early stage of process development
Synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates
Beilstein J. Org. Chem. 2014, 10, 1261–1266, doi:10.3762/bjoc.10.126
- Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China Process Development and Manufacturing Department, Pharmaron (Beijing) Co. Ltd, 6 Taihe Road, BDA, Beijing, 100176, China 10.3762/bjoc.10.126 Abstract A class of novel, easily accessible and air-stable 1-[bis(trifluoromethyl)phosphine]-1
Flow synthesis of phenylserine using threonine aldolase immobilized on Eupergit support
Beilstein J. Org. Chem. 2013, 9, 2168–2179, doi:10.3762/bjoc.9.254
- intensification and biocatalysis has been reviewed [24]. Asanomi et al. have also summarized the use of microfluidic devices in biocatalysis and compared them with conventional batch reactors [25]. The advantages of enzymatic microreactors have been demonstrated both in process development and for the production
Enantioselective synthesis of planar chiral ferrocenes via palladium-catalyzed annulation with diarylethynes
Beilstein J. Org. Chem. 2013, 9, 1891–1896, doi:10.3762/bjoc.9.222
- Yan-Chao Shi Rong-Fei Yang De-Wei Gao Shu-Li You State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China Process Development and Manufacturing Department, Pharmaron (Beijing) Co. Ltd., 6 Taihe
Camera-enabled techniques for organic synthesis
Beilstein J. Org. Chem. 2013, 9, 1051–1072, doi:10.3762/bjoc.9.118
- distribution calculated by using Malvern software, were used to optimise the crystallisation of an advanced pharmaceutical intermediate (Figure 14c) directly on an industrial scale. This eliminated the need for time-intensive process development at intermediate scales; the authors state that the development of
Reductions of aldehydes and ketones with a readily available N-heterocyclic carbene borane and acetic acid
Beilstein J. Org. Chem. 2013, 9, 675–680, doi:10.3762/bjoc.9.76
- , not the NHC-borane. Thus, the acid does not consume a hydride equivalent of NHC-BH3, and a stoichiometric amount of H2 gas (a safety hazard on a large scale) is not produced. Further research and process-development work are needed before one can conclude that diMe-Imd-BH3 and related carbene boranes
Synthesis of compounds related to the anti-migraine drug eletriptan hydrobromide
Beilstein J. Org. Chem. 2012, 8, 1400–1405, doi:10.3762/bjoc.8.162
- palladium on carbon (Scheme 5). The contamination of this impurity in eletriptan hydrobromide (1) was 0.10–0.20%. This impurity can be controlled by tightening up the in-process control of the N-acetyl bromoindole pyrrolidine during the Heck reaction. During the initial process development of eletriptan
Themed series in organo- fluorine chemistry
Beilstein J. Org. Chem. 2008, 4, No. 11, doi:10.3762/bjoc.4.11
- /Deoxofluor, HF:amine reagents and TBAF have secured a central role in the armory of organic chemists and the ready availability and improvements in their formulations are allowing these reagents to be incorporated beyond the research lab and into process development. Indeed micro-reactor technology is
Development of potential manufacturing routes for substituted thiophenes – Preparation of halogenated 2-thiophenecarboxylic acid derivatives as building blocks for a new family of 2,6-dihaloaryl 1,2,4-triazole insecticides
Beilstein J. Org. Chem. 2007, 3, No. 23, doi:10.1186/1860-5397-3-23
- -thiophenecarbonitrile 3 paved the way for the development of viable commercial processes for XR-693 and XR-906, members of a new class of 2,6-dihaloaryl 1,2,4-triazole insecticides that exhibit selective activity against aphids, mites, and whiteflies coupled with low mammalian toxicity. The process development work for
- XR-906. A summation of the process development work of these two new insecticides will be the focus of a forthcoming publication. Experimental See Supporting Information File 1 for full experimental data Thiophene structures 1, 2, and 3. XR-693 and XR-906. Synthesis and Reactivity of 2,4,5-Tribromo-3
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